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Liraglutide, with a half-life of 11–15 h, produces daily peaks and troughs and is more amenable to time-of-day tailoring, whereas semaglutide (half-life ~165–168 h) and tirzepatide (half-life ~117 h) provide near-continuous receptor engagement across the 24 h cycle with once-weekly dosing [75,76]
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The benefits of these medications for glycaemic control and cardiovascular risk reduction generally outweigh the potential pancreatic risks in appropriately selected patients
